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What was once viewed primarily as a gut-pancreas hormonal axis for postprandial glucose regulation has now emerged as a central therapeutic pathway influencing inflammation, cardiovascular function, renal and hepatic systems, and even neuroendocrine regulation

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GLP-1 agonists significantly reduced kidney deterioration and failure, regardless of diabetes status The biggest and most comprehensive analysis of glucagon-like peptide-1 (GLP-1) receptor agonists on kidney and cardiovascular outcomes shows they have significant benefits in people with and without diabetes